The midfielder has been out with a hamstring issue, but he came off the bench against Benfica on Thursday in the Europa League.
Cedric Soares could come into the defence in place of Hector Bellerin, while further forward the attack might be revamped.
Bukayo Saka, Martin Odegaard and Pierre-Emerick Aubameyang have all just played four matches in 12 days and are due a rest.
As a result, they could be rested at the King Power so the likes of Nicolas Pepe can come into the team.
Arsenal predicted lineup: Leno; Cedric, Luiz, Gabriel, Tierney; Partey, Xhaka; Pepe, Smith Rowe, Martinelli; Lacazette.
Sunday 12.00pm GMT, BT Sport
Venue: King Power Stadium
Arsenal squad from: Leno, Runarsson, Ryan; Bellerin, Cedric, Chambers, Gabriel, Holding, Luiz, Mari, Tierney; Ceballos, Elneny, Odegaard, Partey, Saka, Smith Rowe, Xhaka; Aubameyang, Balogun, Lacazette, Martinelli, Nelson, Nketiah, Pepe and Willian.
Doubts: Rob Holding (concussion protocols)