Several players will be rested ahead of Sunday’s trip to Tottenham. Alex Runarsson will come in for Bernd Leno in goal, while the defence will have changes too.
Gabriel Magalhaes and Kieran Tierney should both be given the night off, while Hector Bellerin is expected to be rested too.
A number of youngsters are pushing to play, such as Emile Smith Rowe, Folarin Balogun and Miguel Azeez, but Arsenal also need to give minutes to more senior players.
Alexandre Lacazette could captain the side again from a new position as a No10 and Eddie Nketiah should play as the main striker.
Arsenal predicted line-up (4-2-3-1): Runarsson; Cedric, Mustafi, Kolasinac, Maitland-Niles; Elneny, Willock; Pepe, Lacazette, Nelson; Nketiah.
Arsenal squad from: Leno, Macey, Runarsson; Bellerin, Cedric, Chambers, Gabriel, Holding, Mustafi, Tierney; Azeez, Ceballos, Cottrell, Maitland-Niles, Smith Rowe, Willock, Xhaka; Aubameyang, Balogun, Nelson, Nketiah, Lacazette and Pepe.
Injured: Luiz (head), Mari (ankle), Martinelli (knee) and Partey (thigh).