The pair have slipped down the attacking pecking order in recent weeks following the rise of the likes of Emile Smith Rowe.
Mikel Arteta, however, is expected to make changes for Saturday’s fourth round tie at St Mary’s and Pepe and Willian could start.
Eddie Nketiah is another who could be handed some minutes, while Gabriel Martinelli is pushing to play after returning to full fitness.
In midfield, Mohamed Elneny should come in and Dani Ceballos is hoping to be fit in time as he recovers from a tight calf.
Calum Chambers will hope to get a rare start in defence, while Gabriel Magalhaes is primed to make his first appearance since recovering from Covid-19.
Arsenal predicted XI (4-2-3-1): Leno; Cedric, Chambers, Gabriel, Tierney; Ceballos, Elneny; Pepe, Willian, Martinelli; Nketiah
Saturday 12.15pm GMT, BBC
Venue: St Mary’s Stadium
Arsenal squad from: Leno, Runarsson; Bellerin, Cedric, Chambers, Gabriel, Holding, Luiz, Mustafi, Tierney; Ceballos, Elneny, Maitland-Niles, Partey, Saka, Smith Rowe, Willock, Xhaka; Aubameyang, Balogun, Lacazette, Martinelli, Nelson, Nketiah, Pepe and Willian.
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