Kante has suffered a minor hamstring strain, while James is yet to recover from the same issue in time for Sunday’s game.
But the right-back is nearing a return and is expected to be available for Chelsea’s clash with Fulham next week. Andreas Christensen is also out of the Morecambe game, but he is close to recovering from a knee injury.
Frank Lampard has called up a host of academy players to bolster his squad ahead of the match after new Covid-19 regulations allowed clubs to expand their bubbles.
Henry Lawrence, Lewis Bate, Tino Anjorin, Tino Livramento and Jude Soonsup-Bell have all been training with the first team this week.
Lampard said: “It’s a great experience for them and it’s something I’ve wanted to do and last season was able to do pre-restart.
“It helps training because it’s really important to have competitive training and having young players enables you to be really competitive with killing the other players physically in between games.”
Lampard also defended Christensen after the defender was criticised for staying down in the build to Aston Villa’s equaliser in their 1-1 draw with Chelsea over Christmas.
He confirmed his knee injury had been sustained in that challenge with Jack Grealish.
“It was absolutely from that moment in the Villa game,” said the Chelsea manager. “It’s probably a typical modern-day reaction where Andreas has taken stick.
“He’s out, but the injury isn’t too bad which is good news for him. He’ll be back training with us tomorrow.”
Chelsea predicted XI (4-3-3): Kepa; Azpilicueta, Rudiger, Tomori, Emerson; Havertz, Jorginho, Gilmour; Hudson-Odoi, Abraham, Ziyech