United begin their Europa knockout campaign with a round-of-32 first-leg tie away from home, though Juventus Stadium in Turn, Italy will host the game due to travel restrictions between the UK and Spain.
Summer signings Cavani and Van De Beek have muscle injuries, while manager Ole Gunnar Solskjaer has confirmed a thigh complaint will keep Pogba out for the rest of February.
“He’s recovering well, he’s starting the treatment,” Solskjaer said of Pogba.
“It’ll still be a good few weeks, so he won’t be playing in February, that’s for sure. Still a few weeks until we see Paul, definitely.”
Anthony Martial and Scott McTominay have travelled to Italy for the last-32 first leg but face fitness tests on Thursday, while Juan Mata is involved after missing recent squads.
Meanwhile, teenagers Amad Diallo and Shola Shoretire are included. Neither player has yet to make their senior United debut.
Man Utd predicted lineup: Henderson; Williams, Bailly, Maguire, Telles; Matic, Fred; Greenwood, Fernandes, James; Rashford
Manchester United squad: De Gea, Henderson, Grant, Bailly, Lindelof, Maguire, Shaw, Telles, Tuanzebe, Wan-Bissaka, Williams, Diallo, Fernandes, Fred, James, Mata, Matic, McTominay, Shoretire, Greenwood, Martial, Rashford
Additional reporting by PA.