Mourinho has big decisions at both ends of the pitch following the abject loss to Chelsea.
Centre-half Eric Dier is likely to pay the price for another costly error by dropping out of the side for Joe Rodon, who had started the three previous fixtures before Chelsea and was unfortunate to be overlooked on Thursday.
Harry Winks could also return to the midfield in place of Moussa Sissoko, giving Spurs another passer – which feels essential while Harry Kane, Giovani Lo Celso and Sergio Reguilon remain sidelined.
Erik Lamela is also pushing for his first start since November in the front three after an impressive cameo from the bench against the Blues and Steven Bergwijn could be the fall guy following another uninspiring display.
With Kane not expected back until Wednesday or next weekend, Mourinho is likely to persist with Carlos Vinicius up front.
Spurs predicted lineup (4-2-3-1): Lloris; Aurier, Alderweireld, Rodon, Davies; Hojbjerg, Winks; Lamela, Ndombele, Son; Vinicius.
Spurs squad from: Lloris, Hart, Whiteman, Aurier, Doherty, Tanganga, Dier, Alderweireld, Sanchez, Rodon, Davies, Hojbjerg, Sissoko, Winks, Ndombele, Devine, Lamela, Bergwijn, Lucas, Bale, Son, Vinicius.
Injured: Kane (ankles), Reguilon (hamstring), Dele (calf), Lo Celso (hamstring)
Last meeting: West Brom 0-1 Spurs