Gareth Bale changed the game from the bench in last weekend’s defeat to West Ham before scoring against Wolfsberger again on Wednesday, and the Wales forward is expected to be rewarded with just a third League start of the season.
Dele Alli was also impressive in the Europa League round-of-32 second leg, scoring a brilliant bicycle kick and getting two assists, but an appearance from the bench seems more likely for the 24-year-old, with Mourinho saying on Friday he was still working his way back to fitness.
Lucas Moura could be rewarded for a goal against the Hammers with another start at No10, although Steven Bergwijn and Erik Lamela are also in contention.
Mourinho seems set to stick with struggling defensive pair Eric Dier and Davinson Sanchez, meanwhile.
Tottenham predicted XI (4-2-3-1): Lloris; Tanganga; Sanchez, Dier, Reguilon; Hojbjerg, Ndombele, Bale, Lucas, Son; Kane.
Venue: Tottenham Hotspur Stadium, Sunday 28 February, 14.00, Sky Sports
Spurs squad from: Lloris, Hart, Whiteman, Aurier, Tanganga, Doherty, Reguilon, Davies, Sanchez, Alderweireld, Dier, Rodon, Hojbjerg, Ndombele, Sissoko, Winks, Dele, Bergwijn, Lamela, Bale, Lucas, Son, Kane, Vinicius.
Last meeting: Burnley 0-1 Spurs (Son)