Mourinho has called on Gareth Bale to step up and the Welshman can expected to come in on the right of the front three at the Amex, having scored against the Seagulls in November, with Heung-min Son moving up front.
Without his first-choice wing-backs, a move back to a four-man defence would make sense, with Mourinho having said Joe Rodon will keep his place despite a costly mistake in the build-up to Sadio Mane’s goal on Thursday.
The extra spot in midfield could be filled by Harry Winks, with Giovani Lo Celso and Dele Alli also set to remain on the sidelines this weekend.
Tottenham predicted XI (4-2-3-1): Lloris; Doherty, Rodon, Dier, Davies; Hojbjerg, Winks; Bale, Ndombele, Bergwijn; Son.
Venue: The Amex Stadium, Sunday January 31, 19.15, Sky Sports
Spurs squad from: Lloris, Hart, Gazzaniga, Aurier, Doherty, Alderweireld, Sanchez, Dier, Rodon, Tanganga, Davies, Hojbjerg, Gedson, Sissoko, Ndombele, Winks, Bale, Lucas, Lamela, Vinicius, Bergwijn, Son.
Injured: Kane (ankles), Alli (tendon), Reguilon (hamstring), Lo Celso (hamstring)
Last meeting: Spurs 2-1 Brighton