But with five substitutes available, the Spurs manager can afford to play a strong team in pursuit of an early lead, as he did the first leg of the last-32 against Austrian side Wolfsberger.
The big question for Mourinho is whether to start with Harry Kane and Heung-min Son in the midst of a gruelling month and ahead of Sunday’s crucial north London derby at Arsenal, where Spurs are aiming to make it four League wins on the bounce.
With Carlos Vinicius and Steven Bergwijn set to be among the subs, Mourinho can afford to give the pair an hour or so from the off, and still save their legs for Arsenal.
But Gareth Bale could drop out after starting all three League matches last week, with Mourinho saying again on Thursday that he needed to keep managing the Welshman’s minutes.
That would pave the way for Erik Lamela to come in, while Dele Alli is also expected to return at No.10.
Mourinho has already said that Pierre-Emile Hojbjerg is set to be rested, so Harry Winks could keep his place in the midfield, with Tanguy Ndombele returning.
Toby Alderweireld could do with a rest but the Belgian has formed a solid partnership with Davinson Sanchez in recent weeks, while his likely replacement Eric Dier has tended to look shaky alongside the Colombian. That is another big decision for Mourinho to make.
Giovani Lo Celso remains unavailable with back pain despite recovering from a hamstring injury, while Joe Rodon is ineligible.
Tottenham predicted lineup (4-2-3-1): Lloris; Doherty, Sanchez, Dier, Reguilon; Winks, Ndombele; Lamela, Dele, Son; Kane.
Venue: Tottenham Hotspur Stadium, Thursday 11 March, 20.000
Spurs squad from: Lloris, Hart, Whiteman, Doherty, Aurier, Tanganga, Lavinier, Davies, Reguilon, Alderweireld, Dier, Sanchez, Winks, Hojbjerg, Sissoko, Dele, Devine, Lamela, Lucas, Bergwijn, Son, Bale, Vinicius, Kane, Scarlett.
Unavailable: Lo Celso (fitness), Rodon (ineligible)