Heung-min Son deputised for Kane last season but the South Korean is likely to be rested from the start ahead of Sunday’s north London derby, leaving Gareth Bale, Lucas Moura and Dele Alli as contenders to lead the line.
Youngsters Dane Scarlett and Jack Clarke will hope for more minutes after debuting from the bench against Ludogorets last Thursday.
It could be Moussa Sissoko’s turn to start midweek after Tanguy Ndombele’s shift against the Bulgarians, while the remaining seven players should pick themselves, with Mourinho also short of options at the back.
Sergio Reguilon and Toby Alderweireld are both expected to miss the trip but could be back for Arsenal, while Joe Rodon is ineligible, along with Paulo Gazzaniga, Danny Rose and Gedson Fernandes.
Tottenham predicted lineup (4-3-2-1): Hart, Doherty, Sanchez, Tanganga, Davies; Winks, Lo Celso, Sissoko; Dele, Bale; Lucas.
Tottenham squad from: Lloris, Hart, Whiteman, Doherty, Aurier, Cirkin, Davies, Dier, Tanganga, Sanchez, Winks, Sissoko, Hojbjerg, Dele, Clarke, Lo Celso, White, Ndombele, Bale, Lucas, Son, Lamela, Bergwijn, Scarlett.
Injured: Alderweireld (groin), Lamela (achilles), Kane, Vinicius, Reguilon (all unknown)
Venue: Stadion der Stadt Linz
Referee: Paweł Raczkowski (POL)
Last meeting: Spurs 3-0 LASK