Injured Ireland captain Sexton to miss England clash at Twickenham

His replacement, Billy Burns, is going through HIA (head injury assessment) protocols, casting doubt over his involvement this weekend, too.

Centre Henshaw, meanwhile, is ruled out with an abductor strain.

There is better news on wing Jacob Stockdale, who was ruled out of the game against Wales but should return to training this week. 

France have also announced that they will be without fly-half Romain Ntamack when they face Scotland at Murrayfield on Sunday.

Louis Carbonnel has been called up, with Mathieu Jalibert set to start.

Elsewhere, Italy are expected to be without influential Gloucester back row Jake Polledri for the remainder of the Autumn Nations Cup following a serious knee injury suffered against Scotland in Florence.

The Autumn Nations Cup will be available to stream on Amazon Prime Video from November 13.

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