With Jonathan Joseph out with injury, there are two significant inclusions in the centres.
Ollie Lawrence is retained after missing the meeting with Wales with a hip injury, while Harlequins’ centre Joe Marchant also makes the cut.
His only appearance of the Autumn came off the bench against Georgia.
Of those who did not make the 23 last week, Max Malins and Joe Marler make the squad once more, while there is a call-up for Bath lock Charlie Ewels, who started against Georgia.
Backs: Elliot Daly (Saracens, 46 caps) Owen Farrell (Saracens, 87 caps) George Ford (Leicester Tigers, 71 caps) Ollie Lawrence (Worcester Warriors, 3 caps) Max Malins (Bristol Bears, 2 caps) Joe Marchant (Harlequins, 4 caps) Jonny May (Gloucester Rugby, 60 caps) Dan Robson (Wasps, 6 caps) Henry Slade (Exeter Chiefs, 33 caps) Anthony Watson (Bath Rugby, 45 caps) Ben Youngs (Leicester Tigers, 103 caps)
Forwards: Luke Cowan-Dickie (Exeter Chiefs, 25 caps) Tom Curry (Sale Sharks, 27 caps) Ben Earl (Bristol Bears, 7 caps) Charlie Ewels (Bath Rugby, 17 caps) Ellis Genge (Leicester Tigers, 22 caps) Jamie George (Saracens, 53 caps) Jonny Hill (Exeter Chiefs, 3 caps) Maro Itoje (Saracens, 42 caps) Joe Launchbury (Wasps, 68 caps) Joe Marler (Harlequins, 71 caps) Kyle Sinckler (Bristol Bears, 39 caps) Will Stuart (Bath Rugby, 7 caps) Sam Underhill (Bath Rugby, 21 caps) Billy Vunipola (Saracens, 55 caps) Mako Vunipola (Saracens, 63 caps) Jack Willis (Wasps, 2 caps)