Jurgen Klopp’s Reds were in cruise control with maximum points from their opening three group games, but last week’s 2-0 home defeat to Atalanta has blown things wide open.
Liverpool still lead the group with two games remaining, but with Ajax and Atalanta just two points behind, Klopp cannot afford another slip-up and Anfield.
Date, kick-off time and venue
The match will be held behind closed doors at Anfield.
How to watch Liverpool vs Ajax
TV channel: The match will be televised on BT Sport 2, with coverage from 7pm.
Live stream: BT Sport subscribers will be able to watch the match online via the video player and the BT Sport app.
Joel Matip returns to the squad after being rested for Saturday’s draw at Brighton.
Klopp had hoped midfielder Naby Keita might be back from a hamstring injury but he did not train with the squad on Monday evening.
Midfielder James Milner (hamstring) is the latest player to be added to an injury list which includes Virgil Van Dijk, Joe Gomez, Alex Oxlade-Chamberlain and Thiago Alcantara (all knee), Trent Alexander-Arnold (calf) and Xherdan Shaqiri (muscle).
Provisional Liverpool squad: Alisson, N Williams, Matip, R Williams, Robertson, Fabinho, Henderson, Jones, Salah, Firmino, Mane, Adrian, Kelleher, Tsimikas, Koumetio, Cain, Clarkson, Wijnaldum, Minamino, Jota, Origi.
Liverpool predicted lineup: Alisson; N Williams, R Williams, Matip, Robertson; Henderson, Fabinho; Salah, Firmino, Mane; Jota
Liverpool vs Ajax prediction: 1-1 draw
Given that Liverpool could slip out of the qualification places with a defeat, you’d expect a big performance – but much will depend on how drained the Reds are after recent results. Ajax will be right at Liverpool, and could sneak something.
Liverpool vs Ajax head to head (h2h) history and results
Liverpool vs Ajax bettings odds and tips (subject to change)
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