Liverpool vs Manchester United will be played in front of an empty Anfield after the region was moved into Tier 3 of coronavirus restrictions.
They then face another away fixture at Aston Villa in the FA Cup, before their next home game against fierce rivals United on January 17.
It had been hoped 2,000 fans would again be on the Kop for the fixture, but that will now not be the case.
The move in tiers will affect Everton sooner than their Merseyside rivals, with the Toffees to take on West Ham on New Year’s Day at Goodison Park.
They had also hoped to have 2,000 fans present, but both that and their FA Cup clash with Rotherham a week later will be behind closed doors.
Everton said in a statement: “Everton Football Club can confirm that, following the Government’s announcement the Liverpool City Region is moving into Tier Three of the national COVID-19 restrictions, supporters will no longer be able to attend the Premier League fixture with West Ham United at Goodison Park on New Year’s Day.
“As part of the Tier Three restrictions, which come into force from 00.01 GMT on Thursday 31 December, all professional sporting events will be played behind closed doors without supporters present until further notice.
“This includes Friday’s visit of West Ham and the Club’s FA Cup third-round tie with Rotherham United on Saturday, 9 January.”