The England striker was included in a strong line-up as Jose Mourinho looked to return to winning way in the Europa League following last week’s shock defeat to Royal Antwerp.
On his 300th appearance, Kane opened the scoring with a landmark goal, heading home from Lucas Moura’s corner, having already volleyed over the bar after a glorious pass from Harry Winks and struck the post from long range.
Kane then teed up Moura for to double the lead with a tap-in having been played in by a clever Gareth Bale pass as Spurs’ front three combined.
Claudiu Keșerü’s goal soon after the restart gave the hosts a lifeline they barely deserved but Son Heung-Min was sent on by Mourinho and within seconds teed-up Giovani Lo Celso to secure the win.
The win leaves Spurs second in Group J, behind Royal Antwerp on head-to-head, with the Belgians facing LASK later in the evening.
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