Reigning PFA Player of the Year De Bruyne returned from the facial fractures he suffered in last season’s Champions League final defeat by Chelsea to play for Belgium at the European Championship, only to suffer an ankle ligament tear during the tournament.
Meanwhile, fellow playmaker Foden missed out on England’s Euros final defeat to Italy with a foot injury.
Both players were sidelined for last weekend’s 1-0 Community Shield defeat by Leicester, with Pep Guardiola stating that the duo would be out “for a while”, though De Bruyne likely to return ahead of Foden.
The likes of Ederson, Gabriel Jesus, John Stones, Raheem Sterling and Kyle Walker were also absent from Wembley, but are now back in training following their summer international exertions.
It remains to be seen which of that quintet will be fit enough to play some part this weekend, with the likes of Zack Steffen, Nathan Ake and Benjamin Mendy all deputising against Leicester along with youngsters Samuel Edozie and Cole Palmer.
New £100million signing Jack Grealish will be pushing for his maiden City start on Sunday following a 25-minute cameo off the bench at Wembley, but Guardiola said before the Community Shield that the former Aston Villa captain was “not ready to start at all”.
However, he might have to feature from the off here with the likes of Sterling and Jesus not yet up to speed.
Man City predicted lineup (4-3-3): Ederson; Cancelo, Stones, Dias, Mendy; Rodri, Gundogan, Bernardo; Grealish, Ferran, Mahrez
Man City provisional squad: Ederson, Steffen, Carson, Walker, Cancelo, Stones, Ake, Dias, Laporte, Mendy, Zinchenko, Fernandinho, Gunodgan, Rodri, Grealish, Sterling, Torres, Mahrez, Silva, Palmer, Doyle, Jesus.
Sunday 4.30pm BST, Sky Sports
Venue: Tottenham Hotspur Stadium
Injury list: De Bruyne (ankle), Foden (foot)