However, Pep Guardiola tables turned after the interval with Kevin De Bruyne and Riyad Mahrez scoring two valuable away goals for City, while Idrissa Gueye was shown a red card for a horrible lunge on Ilkay Gundogan.
That 2-1 result leaves City as huge favourites to reach a final against either Chelsea or Real Madrid, but first they must keep Neymar and Kylian Mbappe at bay for another 90 minutes.
Date, kick-off time and venue
Manchester City vs PSG is scheduled for an 8pm BST kick-off on Tuesday, May 4, 2021.
The match will be held behind closed doors at the Etihad Stadium, Manchester.
Where to watch Man City vs PSG
TV channel: The match will be televised on BT Sport 2 and BT Sport Ultimate.
Live stream: BT Sport subscribers will be able to watch the match online via the website or BT Sport app.
Man City vs PSG team news
City boast a clean bill of health, with Guardiola also able to give the likes of Gundogan, De Bruyne, Mahrez, Bernardo Silva, Kyle Walker, Ruben Dias and Phil Foden a rest at the weekend.
Those seven players are all likely to start the second leg.
As for PSG, Mbappe may be a doubt after missing their match against Lens on Saturday with a calf problem. While Pochettino will hope that is only a temporary injury, it is unlikely that the World Cup winner will be at 100 per cent.
Man City vs PSG prediction
The nature of the first leg makes this prediction even tougher. PSG were dominant for 45 minutes, but City strolled the second half and should have scored more than twice.
It could all depend on an early goal. PSG need to score at least twice at the Etihad, and if they get one early doors it could turn into a shootout – but City should have just enough to see this one out and reach the final.
Man City vs PSG head to head (h2h) results
Last meeting: PSG 1-2 Man City (28/04/2021)
Man City vs PSG odds and betting tips
Man City to reach the final: 1/10
PSG to reach the final: 11/2
Mbappe to score 2 or more goals: 9/1