Pogba, who has not featured since February 6 due to a thigh complaint, is in the travelling squad along with Van De Beek, while De Gea is back from paternity leave.
Cavani was named in the initial 21-man group, but Ole Gunnar Solskjaer has since confirmed he will not travel after having a negative reaction in training on Wednesday.
Martial is out of the last-16 second leg through injury, while Eric Bailly, Juan Mata and Phil Jones are also absent. Shola Shoretire has stayed at home in order to play for the under-23s.
Manchester United predicted XI: (4-2-3-1) Henderson; Wan-Bissaka, Maguire, Lindelof, Shaw; Fred, McTominay; Greenwood, Fernandes, James; Rashford
Man Utd squad: De Gea, Henderson, Grant, Lindelof, Maguire, Shaw, Telles, Tuanzebe, Wan-Bissaka, Williams, Amad, Fernandes, Fred, James, Matic, McTominay, Pogba, Van De Beek, Greenwood, Rashford
Injury list: Martial, Cavani, Bailly, Mata, Jones
Doubts: Pogba, Van de Beek (both fitness)