Anthony Martial misses out through illness, and Donny van de Beek starts in what looks like a 4-4-2 midfield diamond.
Man Utd XI: de Gea, Wan Bissaka, Lindelof, Maguire, Alex Telles, Fred, Matic, van de Beek, Bruno Fernandes, Rashford, Greenwood
Subs: Cavani, Mata, James, Fosu-Mensah, Henderson, Williams, Tuanzebe
Southampton XI: McCarthy, Walker-Peters, Bednarek, Vestergaard, Bertrand, Armstrong, Ward-Prowse, Romeu, Djenepo, Walcott, Adams
Subs: Stephens, Long, Obafemi, Tella, Diallo, N’Lundulu, Forster
Injured: Anthony Martial (illness), Paul Pogba (ankle), Scott McTominay (knock), Jesse Lingard (fitness), Eric Bailly (fitness), Phil Jones (knee), Luke Shaw (hamstring)
This weekend get a £10 free bet with Betfair, when you bet £10 on a Same Game Multi on the Premier League.
Terms: Min £10 Same Game Multi bet on any EPL match this Fri – Sun. Free bet valid for 72 hours, awarded at bet settlement. Excludes cashed out bets. T&Cs apply.