Maguire missed the midweek away win over Paris Saint-Germain but scored in the 4-1 thumping of Newcastle last weekend.
In his absence, Axel Tuanzebe excelled in a back three alongside Victor Lindelof and Luke Shaw, and Solskjaer could opt for a similar system, or else be forced to decide who partners his returning skipper.
Alex Telles looks likely to keep his place on the left after an impressive debut, while Edinson Cavani could be set to make his.
With Anthony Martial suspended, Solskjaer will be relieved to have both the Uruguayan and Mason Greenwood available as attacking options, though both could start on the bench.
Fred and Scott McTominay started in midfield in Paris but Paul Pogba and Donny van de Beek are both pushing for inclusions today.
Man Utd predicted XI: De Gea, Maguire, Lindelof, Shaw, Telles, Wan-Bissaka, McTominay, Pogba, Fernandes, Greenwood, Rashford
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