Rashford tweaked his knee towards the end of Sunday’s FA Cup fourth-round win against Liverpool, but is back and leads the attack with Anthony Martial.
David de Gea returns in goal after Dean Henderson featured in the cup win, while Axel Tuanzebe has been afforded a rare start in defence alongside Harry Maguire.
Solskjaer has been reluctant to rotate too much recently for fear of disrupting his team’s rhythm, but Bruno Fernandes is back following a match-winning cameo against Liverpool – and that means Donny van de Beek drops out again.
Nemanja Matic comes in next to Paul Pogba in midfield. Luke Shaw has been given a well-deserved rest after a fine run of form with Alex Telles needing minutes, while Martial and Mason Greenwood also play in attack.
Manchester United lineup: de Gea, Wan Bissaka, Tuanzebe, Maguire, Alex Telles, Pogba, Matic, Greenwood, Bruno Fernandes, Martial, Rashford
Subs: Lindelof, Cavani, Mata, Fred, James, Shaw, Henderson, van de Beek, McTominay
Injury list: Marcos Rojo (calf), Phil Jones (knee), Facundo Pellistri (lacing match fitness), Brandon Williams (knock)