Edinson Cavani misses the game with his fitness under continual assessment and Ole Gunnar Solskjaer likely to be patient with the striker ahead of the traditionally hectic festive fixture schedule.
“Of course we have to be mindful of little strains and niggles, and decisions have to be made,” said Solskjaer on Wednesday, whose side face six games in 16 days.
“From the kick-off of Sheffield United to kick-off (against Aston Villa on New Year’s Day) it’s 15 times 24 hours, so it’s going to be very tight.
“Edinson has done well in his rehab. Still have to make a decision if we should risk him because it is a risk, a little bit to him, too early, so I doubt him to be available for me to pick tomorrow.”
Dean Henderson starts in goal against the team he spent two years on loan for, with David de Gea on the bench.
Alex Telles, Paul Pogba, Anthony Martial and Mason Greenwood all start, but Donny van de Beek is yet again a substitute,
Elsewhere, a muscle concern continues to rule Phil Jones out of action, with a return the other side of Christmas more likely, and Marcos Rojo remains out meaning the defender will not have represented United in 2020.
The Blades have just one point to their name after 12 games, a wretched run of form which is in stark contrast it this time last year when they were flirting with the top four.
Manchester United XI: Henderson, Wan Bissaka, Lindelof, Maguire, Alex Telles, Matic, Pogba, Greenwood, Bruno Fernandes, Martial, Rashford
Subs: de Gea, Mata, Fred, James, Shaw, van de Beek, McTominay
Ole Gunnar Solskjaer on return of Dean Henderson
Sheffield United vs Manchester United, Thursday December 17, 8pm GMT
Injured: Phil Jones (muscle)
Manchester United squad from: De Gea, Henderson, Grant, Wan-Bissaka, Fosu-Mensah, Lindelof, Maguire, Mengi, Tuanzebe, Telles, Shaw, Williams, Fred, Pogba, McTominay, Fernandes, Matic, Van De Beek, Lingard, James, Mata, Ighalo, Martial, Rashford.
Last meeting: Manchester United 3-0 Sheffield United
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