Alex Telles tested negative for coronavirus during the international break, and is named at left-back.
Up front, Marcus Rashford sat out England duty with a shoulder injury and has spent the last week or so back at Carrington – but he starts here.
Anthony Martial also starts, but Mason Greenwood has been left out of the squad.
Donny van de Beek is still waiting for his first League start since arriving, and there is no room for Paul Pogba in the squad.
Manchester United lineup: de Gea, Wan Bissaka, Lindelof, Maguire, Alex Telles, Matic, Fred, Mata, Bruno Fernandes, Rashford, Martial
Subs: Cavani, James, Henderson, Williams, Van de Beek, Tuanzebe, McTominay
West Brom lineup: Johnstone, Furlong, Ajayi, Bartley, Ivanovic, Townsend, Matheus Pereira, Sawyers, Gallagher, Diangana, Ahearne-Grant
Subs: Robson-Kanu, Robinson, Phillips, Harper, Krovinovic, Button, O’Shea
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