The England forward was replaced by fit-again match-winner Paul Pogba at half-time during Thursday’s Europa League last-16 second-leg win over AC Milan with what manager Ole Gunnar Solskjaer described as a “twinge”.
The usually ever-present Rashford also missed the first leg against the Italians with a slight issue, and has not been risked today.
There is better news for Solskjaer with Anthony Martial, Paul Pogba and Donny van de Beek all fit to start after recent injury absences, while Edinson Cavani returns as a substitute.
Eric Bailly, Juan Mata and long-term absentee Phil Jones all remain sidelined, while Dean Henderson keeps his place in goal over David de Gea – though this being a cup game ahead of the international break, Solskjaer arguably has no need to decide whether De Gea will take back the No1 spot just yet.
Manchester United lineup: Henderson; Wan-Bissaka, Lindelof, Maguire, Telles; Fred, Matic; Greenwood, van de Beek, Pogba; Martial
Subs: De Gea, Shaw, Tuanzebe, Williams, Amad, Fernandes, James, McTominay, Cavani
Injury list: Mata, Jones, Rashford