United currently sit second in the Premier League table, while top-four rivals Leicester City (third) and Chelsea (fourth) both lost this weekend to offer the Red Devils the chance to capitalise.
With Tottenham also drawing to miss the chance to go fourth, United could go 11 points clear of fifth-placed Liverpool if they beat Graham Potter’s Seagulls at the Theatre of Dreams.
With United crashing out of the FA Cup to Leicester before the international break and Man City running away with the title, a strong League finish and potential Europa League glory are the immediate aims for Solskjaer’s squad.
Though the big prizes on offer at the start of the season are beyond United, Solskjaer will want his side to finish the season as strongly as possible as he looks to build a squad capable of competing for top honours next year.
With kick-off at 7:30pm BST, follow all the action on our LIVE blog!
A lot could depend on the attacking options available to Solskjaer with Rashford, Greenwood and Martial all doubts, but even so his side should have too much quality against a Brighton side who may play into their hands by committing bodies forward.
Early Brighton team news
Brighton are hopeful Aaron Connolly will be available as the striker trained on Friday despite heavy bruising on his foot.
Adam Webster could return from an ankle injury against Everton next week but the trip to Old Trafford comes too soon, while Percy Tau is now quarantining after featuring for South Africa during the international break.
Tariq Lamptey and Solly March remain on the sidelines.
Man Utd predicted lineup and team news
United are likely to be without Anthony Martial, but Solskjaer is hopeful of having Mason Greenwood and Marcus Rashford available after both missed the international break through injury.
Victor Lindelof also missed training with an ongoing back complaint, while Solskjaer refused to confirm whether David De Gea or Dean Henderson will start in goal tonight.
Predicted lineup: Henderson; Wan-Bissaka, Maguire, Lindelof, Shaw; Fred, McTominay, Pogba; Fernandes, Rashford, Cavani
Man Utd vs Brighton: Where to watch
TV channel: Tonight’s match will be televised live on BT Sport 1 and BT Sport Ultimate, with coverage beginning at 7pm.
Live stream: BT Sport subscribers will be able to watch the match online via the website or app.
Hello and welcome to our live coverage of tonight’s Premier League clash between Manchester United and Brighton!
Kick-off is at 7:30pm BST at Old Trafford, and we will keep you up to date with all the match action as it happens.