Joel Matip has been taken off at half-time during Liverpool’s visit to Fulham to potentially deepen Jurgen Klopp’s injury crisis.
The German has had to work without a host of his first team stars this term.
But his options at centre-half have been thoroughly tested with Virgil van Dijk and Joe Gomez both set for long-term absences.
Klopp has already been utilising Fabinho as a makeshift centre-half alongside Matip.
But the Cameroon international was feeling a pain in his back and has been replaced at the break.
It means Jordan Henderson has been forced to drop in to leave the Reds with a hugely unorthodox backline at Craven Cottage.
It makes a bad week even worse after it emerged that Diogo Jota will be out for two months.
The forward, who was signed from Wolves in the summer, has been hugely prolific this term.
Klopp confirmed his knee injury picked up against FC Midtjylland in midweek was worse than first thought.
Jota was injured close to the end of Liverpool’s 1-1 draw in the Champions League.
“Yeah, it’s worse than we first thought and better than we then thought,” Klopp said before kickoff in their Premier League clash at Fulham on Sunday.
“All the potential surgeons had a look on it, no surgery needed.
“But he will be out for a while. We don’t know exactly but one-and-a-half, two months. It’s pretty similar with Kostas Tsimikas, by the way. Unbelievable.”
Mohamed Salah also fell foul to the illness but has since returned.
Trent Alexander-Arnold is another key man to face time out but has reprised his usual right-back role since recovering.