The in-form Hammers welcome the champions to the London Stadium having run them close at Anfield in October, taking an early lead before Mo Salah equalised and Diogo Jota stole the points with a late winner.
Moyes was without talisman Antonio for that game but the striker is now back to full fitness and back at full steam, scoring winners against Burnley and West Brom and hitting the post twice in the 3-2 win at Crystal Palace which took West Ham temporarily above Liverpool into fourth.
And with Liverpool forced to field a patched-up defence, Moyes will be hoping his explosive frontman can inflict further damage on their title bid and lift West Ham back into the Champions League spots.
“I think Mickey’s made a difference to us all, certainly over the last year he’s made a really big difference,” said the Hammers boss.
“I hope his form continues. I think the other night against Palace was a night he could have ended up with three or four goals.
“The two games prior to that he got me the winning goals. So he’s really important to us. And I do believe that going to Anfield, if we’d had Mickey he’d have given us a better chance to get the result.
“I hope that proves to be the case in this game and that we can play as well, and that Mickey has his shooting boots on to give us the extra that we need.”
Additional reporting by PA.