After his Australian Open triumph, the Spaniard downed new world No1 Daniil Medvedev in the semi-final to set up a clash with British No1 Norrie, who had defeated Stefanos Tsitsipas to reach a second successive ATP final.
Nadal broke midway through the first set to take a 3-2 lead and never looked back as he swooped to a fourth Mexican Open crown.
Norrie was broken in the opening game of the next set before he hit back to be a 1-1, but the world number five broke him again in the fifth game to go ahead 3-2.
Nadal broke Norrie a third time to take a 5-2 lead, yet the younger man rallied to pull a break back before running out of energy to fall 6-4 6-4 in an hour and 54 minutes.
Nadal’s four titles – he has previously won in 2005, 2013 and 2020 – have him equal with David Ferrer and Thomas Muster as the most successful male players at Acapulco.
Additional reporting by PA Media.