Keen to make up for lost time after missing out on qualification for both Euro 2016 and the 2018 World Cup in Russia, the Oranje have made an impressive start to their major tournament return on home soil.
A thrilling 3-2 win over Ukraine in Amsterdam was followed by a far more comfortable 2-0 defeat of Austria on Thursday night, securing top spot with a game to spare.
Frank de Boer could therefore decide to ring the changes in this final group contest with first place already guaranteed in order to rest some of his key stars for the knockout challenges ahead.
The likes of Nathan Ake, Davy Klaassen, Ryan Gravenberch and Donyell Malen will all be pushing to start at the Johan Cruyff Arena and make a good impression ahead of the last 16.
North Macedonia are already assured to finish bottom of the pile in Group C on their major tournament debut after back-to-back defeats by Austria and Ukraine, though showed strong fighting spirit against the latter with a spot-kick from Leeds’ Ezgjan Alioski and late penalty save courtesy of goalkeeper Stole Dimitrievski.
Manager Igor Angelovski is not expected to shake up his side for their final contest.
Here is how we predict the two sides will shape up…
North Macedonia vs Netherlands predicted lineups
North Macedonia XI: Dimitrievski; S Ristovski, Velkovski, Musliu, Nikolov, Ademi, Alioski, Bardi, Spirovski; Pandev, Elmas
Netherlands XI: Stekelenburg; Dumfries, De Ligt, Ake, Blind, Van Aanholt; Klaassen, Gravenberch, Wijnaldum; Depay, Malen
Goalkeepers: Stole Dimitrievski, Damjan Siskovski, Riste Jankov
Defenders: Stefan Ristovski, Visar Musliu, Egzon Bejtulai, Kire Ristevski, Gjoko Zajkov, Darko Velkovski, Ezdzan Alioski
Midfielders: Arijan Ademi, Enis Bardhi, Stefan Spirovski, Boban Nikolov, Tihomir Kostadinov, Ferhan Hasani, Eljif Elmas, Daniel Avramovski, Darko Curlinov, Marjan Radeski
Forwards: Goran Pandev, Aleksandar Trajkovski, Ivan Trickovski, Vlatko Stojanovski, Krste Velkovski, Milan Ristovski
Goalkeepers: Jasper Cillessen, Tim Krul, Maarten Stekelenburg
Defenders: Nathan Ake, Daley Blind, Matthijs de Ligt, Stefan de Vrij, Denzel Dumfries, Jurriem Timber, Patrick van Aanholt, Joel Veltman, Owen Wijndal
Midfielders: Frenkie de Jong, Marten de Roon, Ryan Gravenberch, Davy Klaassen, Teun Koopmeiners, Georginio Wijnaldum
Forwards: Steven Berghuis, Luuk de Jong, Memphis Depay, Cody Gakpo, Donyell Malen, Quincy Promes, Wout Weghorst