Antonio Conte’s side edged past League One side Portsmouth in the third round and they now come up against Championship opposition, as they target a run in a competition that could bring a lift in spirits.
It is certainly Spurs’ best chance of silverware this season and they are strong favourites to make it through to the fifth round, even if Conte opts to shuffle his pack.
Preston sit 11th in the Championship table and goals continue to be a problem, with just 26 scored in their 28 league games.
This is a fragile Tottenham defence though, and the free-hit nature of tonight’s clash could inspire a bit more attacking ambition.
Where to watch Preston vs Tottenham
TV channel: In the UK, the match will be televised live and free-to-air on BBC One, with coverage beginning at 5:40pm.
Live stream: Fans can also catch the game live online via the BBC iPlayer app and BBC Sport website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.