Ole Gunnar Solskjaer is hopeful two players could return to fitness in time to face Manchester City.
It comes as Manchester United come up against a team that are on a 21-match winning streak.
There is a lot at stake for the Red Devils, who are currently 14 points behind their local rivals in the Premier League.
City look like they are ready to run away with the title and could stretch their lead over their second-placed nemesis to 17 points on Sunday.
With 10 matches left, that would surely be too big a mountain to climb – and they may even be the case if United get the win.
But Solskjaer is sticking to his word and aims to push City as far as possible in the title race.
And his case could receive a major boost with Paul Pogba and Anthony Martial close to returning to fitness.
“We’re still hoping to get one or two back of course,” Solskjaer told MUTV on Friday.
“We can’t promise any of them being available that weren’t available in the last game against Palace.
“So we’ll go with the same squad if not.”
Pogba has not played since the 3-3 draw against Everton in February after being suffering a thigh injury.
Martial had a knock in training which ruled him out of the Palace clash while Victor Lindelof was an unused substitute as Solskjaer continues to monitor a long-term back injury.
Dean Henderson looks set to remain in goal with David de Gea back in Spain for the birth of his child.