United hammered rivals Leeds 5-1 at Old Trafford last weekend, with the likes of Paul Pogba and Bruno Fernandes in magnificent form, while Raphael Varane was unveiled in front of the returning home fans and Jadon Sancho made his debut.
Saints, meanwhile, began with a 3-1 defeat to Everton at Goodison Park, but there was at least some positive news this week as star man James Ward Prowse put pen to paper on a new five-year contract.
Where to watch Southampton vs Man United
TV channel: The match will be televised on Sky Sports’ Main Event and Premier League channels, with kick-off at 2pm BST.
Live stream: Sky Sports subscribers will be able to watch the match online via the SkyGo app.
Live coverage: Standard Sport will bring you all the match action, analysis and reaction.
Read our dedicated match preview here.