Erik Lamela and Japhet Tanganga have returned to light training but are unlikely to be ready to play at the bet365 Stadium.
Mourinho faces decisions throughout his team but he may opt to keep the spine of Hugo Lloris, Toby Alderweireld, Pierre-Emile Hojbjerg and Harry Kane in place – and make changes around it.
Matt Doherty is due a start, particularly after Serge Aurier’s horror show on Sunday, while Ben Davies, Harry Winks and Davinson Sanchez will also be eyeing minutes.
Gareth Bale can expect to start after playing a half against Leicester, while Steven Bergwijn may also return to the front three.
Dele Alli will also be desperate for a run out but it seems unlikely he would go straight into the XI after being left off Mourinho’s nine-man bench against the Foxes.
Predicted Tottenham XI (4-2-3-1): Lloris; Doherty, Sanchez, Alderweireld, Davies; Hojbjerg, Winks; Bergwijn, Bale, Lucas; Kane.
Wednesday, December 23, 5.30pm, Sky Sports
Tottenham squad from: Lloris, Hart, Gazzaniga, Whiteman, Doherty, Aurier, Rodon, Alderweireld, Davies, Reguilon, Dier, Sanchez, Winks, Sissoko, Hojbjerg, Dele, Clarke, Lo Celso, Ndombele, Bale, Lucas, Son, Bergwijn, Vinicius, Kane.
Injury doubts: Lo Celso, Lamela, Tanganga
Last meeting: Stoke 1-2 Tottenham