Spurs were originally due to travel to Croatia for the first leg, but the hosts were switched due to Arsenal playing at home on the same day.
So, Jose Mourinho and his team will be looking to build up a strong advantage at home before a potentially ticky away trip.
Date, time and venue
Tottenham vs Dinamo Zagreb is scheduled for an 8pm GMT kick-off on Thursday, March 11, 2021.
The match will be held behind closed doors at Tottenham Hotspur Stadium.
How to watch
TV channel: The match will be televised on ESPN.
Live stream: BT Sport subscribers will be able to watch the match online via the website or BT Sport app.
Giovani Lo Celso is out after suffering a fitness setback, while Gareth Bale may be rested ahead of the north London derby.
Expect Harry Kane and Heung-min Son to start, though. Eric Dier should come into defence, while Ben Davies will be hoping for more minutes following the return of Sergio Reguilon.
Harry Winks started against Crystal Palace and may keep his place, with either Tanguy Ndombele or Pierre-Emile Hojbjerg partnering him.
Prediction: Tottenham 2-0 Dinamo Zagreb
Jose Mourinho will make changes but still keep the line-up strong enough to beat the Croatians, with the Spurs boss no doubt aware of their impressive defence record of seven clean sheets in their last eight games.
Head to head (h2h) history and results
Tottenham and Dinamo Zagreb have met just once before, in the Uefa Cup group stage in November 2008. Darren Bent scored a hat-trick in a 4-0 win at White Hart Lane.
Betting odds and tips (subject to change)
- Tottenham win: 2/5
- Draw: 15/4
- Dinamo Zagreb win: 7/1
- Spurs to win 1-0: 7/1