Alderweireld missed the game against Chelsea with a groin strain but returned to training this week.
Kane also returns after an unspecified problem ruled him out on Thursday, but Tanguy Ndombele misses out in midfield.
Carlos Vinicius is on the bench despite being a doubt, while Erik Lamela remains sidelined.
Tottenham XI: Lloris, Aurier, Alderweireld, Dier, Reguilon, Sissoko, Hojbjerg, Son, Lo Celso, Bergwijn, Kane
Subs: Winks, Bale, Hart, Rodon, Lucas Moura, Davies, Vinicius
Today 4.30pm GMT, Sky Sports
Venue: Tottenham Hotspur Stadium
Tottenham squad from: Lloris, Hart, Gazzaniga, Whiteman, Doherty, Aurier, Rodon, Alderweireld, Cirkin, Davies, Reguilon, Dier, Tanganga, Sanchez, Winks, Sissoko, Hojbjerg, Dele, Clarke, Lo Celso, White, Ndombele, Bale, Lucas, Son, Lamela, Bergwijn, Scarlett, Vinicius, Kane.
Injured: Lamela (achilles)
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