The Welshman did not look fully up to speed in an hour run out against LASK, despite bagging an assist.
Tanguy Ndombele was also given a night off in the Europa League and the Frenchman lines up in midfield Pierre-Emile Hojbjerg and Moussa Sissoko.
At the back, Mourinho brings in Eric Dier after missing the last two games through injury and Davinson Sanchez uncomfortable on the left of a back two in the 3-3 draw with West Ham.
Ben Davies also starts with Sergio Reguilon on the bench, while Heung-min Son, Harry Kane and Lucas Moura start in attack.
Burnley XI: Pope, Lowton, Long, Tarkowski, Taylor, Gudmundsson, Westwood, Brownhill, McNeil, Barnes, Wood
Subs: Brady, Peacock-Farrell, Stephens, Rodriguez, Vydra, Dunne, Benson
Tottenham XI: Lloris, Doherty, Alderweireld, Dier, Davies, Sissoko, Hojbjerg, Lucas Moura, Ndombele, Son, Kane
Subs: Reguilon, Bale, Lamela, Hart, Rodon, Lo Celso, Vinicius
Referee: Michael Oliver