The Spurs manager has already named Gareth Bale in the XI and the Welshman could be joined in the front three by Harry Kane, who was rested from the start in the first two group games but was needed from the bench in Belgium.
Mourinho has so far rotated his goalkeepers in the competition, so Joe Hart will be hoping for the nod after Hugo Lloris played last week.
With Sergio Reguilon (flu) and Serge Aurier sidelined, Mourinho’s full-backs pick themselves but he could opt to rest Eric Dier for Davinson Sanchez.
In midfield, Giovani Lo Celso needs minutes after an impressive cameo against Brighton and Mourinho said Spurs missed Tanguy Ndombele last Thursday, so the pair could start together for the first time this season.
Japhet Tanganga is back in training but unlikely to be risked from the start in Spurs’ second visit to Bulgaria this season.
Asked about absentees, Mourinho said: “Reguilon is ill but not the Covid situation at all, just flu.
“We don’t want him to be with the team, he could, but we don’t want him to because that position we have two great players and professionals.
“Ben Davies is Ben Davies so no problem with that. Erik Lamela has a little problem for a few weeks and after the last match we decided it’s the moment to stop and have this week plus the two weeks of internationals for him to recover fully.
“Aurier has a little problem, nothing important but he decided with the medical team that he didn’t want to risk [playing tomorrow].”
Joe Rodon, Gedson Fernandes, Danny Rose and Paulo Gazzaniga are ineligible.
Spurs predicted XI (4-3-3): Hart; Doherty, Sanchez, Alderweireld, Davies; Sissoko, Ndombele, Lo Celso; Bale, Kane, Lucas.
Thursday 17.55 GMT, BT Sport
Spurs squad from: Lloris, Hart, Austin, Whiteman, Doherty, Tanganga, Sanchez, Alderweireld, Dier, Davies, Cirkin, Hojbjerg, Sissoko, Winks, Alli, Lo Celso, Ndombele, White, Clarke, Bale, Bergwijn, Son, Kane, Lucas, Vinicius.
Doubts: Tanganga (fitness)
Injured: Reguilon (ill), Lamela (achilles), Aurier (unknown)
Ineligible: Rodon, Gazzaniga, Rose, Gedson