Steven Bergwijn is also a surprise starter for Spurs over Gareth Bale, while Harry Winks misses out after returning from England duty with a “small problem”. Erik Lamela also remains sidelined with an achilles injury.
Heung-min Son twice tested negative for Covid after an outbreak in the South Korea camp last week and is back here.
Tottenham XI: Lloris, Aurier, Alderweireld, Dier, Reguilon, Sissoko, Hojbjerg, Bergwijn, Ndombele, Son, Kane
Subs: Bale, Hart, Rodon, Lo Celso, Lucas Moura, Davies, Vinicius
Man City XI: Ederson, Walker, Dias, Laporte, Joao Cancelo, De Bruyne, Rodri, Bernardo Silva, Mahrez, Gabriel Jesus, Torres
Subs: Stones, Sterling, Gundogan, Aguero, Steffen, Foden, Garcia
FPL gameweek 9 tips: Hakim Ziyech in demand
Tottenham squad from: Lloris, Hart, Gazzaniga, Doherty, Aurier, Reguilon, Davies, Rodon, Alderweireld, Dier, Tanganga, Sanchez, Gedson, Winks, Sissoko, Hojbjerg, Dele, Clarke, Lo Celso, Ndombele, Bale, Lucas, Lamela, Bergwijn, Kane, Vinicius.
Injured: Lamela (achilles), Doherty (positive Covid test)
Tottenham vs Manchester City, Saturday 21 November, 17.30. Sky Sports
Venue: The Tottenham Hotspur Stadium
Last meeting: Spurs 2-0 Man City