The Blues make the short trip across west London on October 16, but Thiago Silva won’t feature in that derby clash after heading to South America for World Cup qualifiers against Venezuela, Colombia and Uruguay.
The last match of that triple-header, the home meeting with Uruguay in Manaus, is not scheduled to kick-off until 01:30am BST on Friday morning.
Tuchel said of Thiago Silva: “He will go and then he will play for Brazil and then he will come back on the matchday versus Brentford.
“This is the life of international breaks, this is the situation of international breaks in 2021.
“Like it or not, what can I do? Is it a good solution for us as a club? No. But we cannot hold him back.
“It is impossible if they call him, he needs to go. Otherwise he gets suspended from FIFA.
“There is no choice and it is something we have to live with.”