Hammers boss David Moyes has said the forward is fatigued and he could miss the trip to Old Trafford having been substituted as a precaution at Fulham on Saturday.
Moyes decided against replacing sold striker Sebastien Haller in the January window, meaning the Scot will have to be creative if Antonio is unable to go again on Tuesday night.
“It will be a close call whether he makes it or not,” said Moyes. “We’ll need to assess him tomorrow to see if he is able to play.
“It has been well documented that we don’t have a lot of other options. We’re well aware of that and we chose to do it. I didn’t want to waste £15-20million on something I wasn’t sure about so that was the option I chose to take.”
Being without Antonio would be a blow for West Ham, who were today waiting to learn if the controversial red card shown to midfielder Tomas Soucek against Fulham on Saturday would be overturned.
Soucek was dismissed by referee Mike Dean after his elbow made contact with the face of Fulham forward Aleksandar Mitrovic in the final moments of their 0-0 draw at Craven Cottage.
Even Mitrovic told Dean that the Czech midfielder had caught him by accident and Moyes again said on Monday that he was “disappointed” by the officials.
“I can’t plan for him to be in our team,” said Moyes. “I am hoping we get an early response and things are seen in the correct fashion.”