Clarke’s controversial comments, before a Digital, Culture, Media and Sport committee, were branded “harmful”, “archaic” and “deeply offensive”, and he has now stepped down.
Here is a look at how Clarke rose to the position…
Clarke was appointed chairman of the Football Association in 2016 following six years as chairman of the Football League.
Clarke was recommended by the nominations committee, which was chaired by independent director Roger Devlin, after Greg Dyke brought to an end his three years in the post.
Upon announcing his nomination, Devlin said: “The board was in full agreement that Greg was the right appointment to become the new chairman of The FA, particularly with respect to his successful tenure as chairman of the Football League.
“He has the relevant experience and strong credentials to help the organisation and can play a key role in bringing all parts of the English game closer together.
“I am sure Greg will rise to the challenge and make a positive impact at all levels of the game, including the significant investment being made in the grassroots, the work being done across the elite England teams and the day to day operations at our St George’s Park and Wembley homes.”
Clarke has also been a Fifa vice-president since last year.
Part of his role at the Football League included serving on the FA Council.
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Prior to that he was a director and chairman of Leicester, where he worked alongside Martin Glenn, who was later his colleague as FA chief executive until last year.
A successful businessman, Clarke was chief executive officer of Cable & Wireless and sat on the board of Bupa. He was chairman of the Met Office for four years and also chairman of FTSE 250 company Redefine International.
Clarke’s remarks to MPs, which led to his resignation on Tuesday evening, were not the first time his language had put his position under threat.
He had to lead the governing body’s response to allegations of historical sexual abuse in football, and of racism and bullying in relation to the Mark Sampson and Eni Aluko cases.
An investigation concluded that former England women’s manager Sampson made discriminatory remarks towards Aluko and team-mate Drew Spence.
While giving evidence to the DCMS select committee, former England striker Aluko said she was “astonished” at an email from Clarke, in reply to a document about the incident from the Professional Footballers’ Association, which read: “I’ve no idea why you are sending me this. Perhaps you could enlighten me?”
During Clarke’s testimony he tried to deflect the verbal blows he was receiving by attacking the PFA, which had backed Aluko throughout, by suggesting it had let down survivors of football’s child sex abuse scandal.
Clarke also tried to suggest claims that the FA is institutionally racist were “fluff”. He had to quickly retract that, but the damage was done.
Clarke says he will now return to the business world.
Additional reporting by PA.