A tumultuous term has left Wolves 12th in the table while United are second behind rivals Manchester City.
The Red Devils come into the game with an eye on the Europa League final, with rotation in the first XI likely to avoid injury.
Harry Maguire was recently spotted walking without a boot, but Ole Gunnar Solskjaer has since ruled his club captain out of the showdown in Gdansk.
Anthony Martial will also miss the final due to a prolonged knee injury, but winger Dan James and midfielder Scott McTominay may return in time for the trip to Wolves.
Fred went off with a knock last game but might return too.
Solskjaer will be looking at some players’ performances to see if they can bag a place in the starting XI for the final.
The Norwegian will have to choose between either Axel Tuanzebe or Eric Bailly to partner Victor Lindelof in central defence.
Due to the midweek cup final, United could field youngsters such as Amad Diallo against Wolves, while former Ajax star Donny van de Beek could get a rare start.
If United do not lose, they will become only the third ever English club to be unbeaten in away games throughout a top-flight campaign after Preston North End (1888/89) and Arsenal (2001/02 and 2003/04).
Wolves, with only one win in five Premier League games, are without five players due to injury.
Jonny Otto, Pedro Neto, Owen Otasowie, Raul Jimenez, and Daniel Podence are all missing for the final game of the season.
Jimenez is recovering from a serious head injury suffered in late November last year and it is hoped he will return next season.
In a statement, Wolves club doctor Matt Perry said: “Raul was seriously injured six months ago on 29th November and underwent emergency surgery for a major traumatic brain injury and skull fracture (TBI) at St Mary’s Hospital Paddington.
“He has no measurable signs of deficit and is now at the stage when he can contemplate a return to the career he loves; but a degree of caution is still required.”
What time is Wolves vs Man Utd?
Wolves vs Man Utd kicks-off at 4pm, on Sunday 23 May.
All 10 Premier League games this weekend will kick-off at the same time.
Wolves vs Man Utd TV channel and livestream?
The game will be broadcast BT Sport 1, with coverage starting at 3pm.
Fans with the necessary subscription can also tune in on the BT Sport app.