A victory will secure a seeding for the last-16 draw and keep Juventus in second place, while the Italians must better the Blues’ result to jump them.
Thomas Tuchel suffered a fresh blow ahead of the game with the news that Mateo Kovacic will miss out through Covid-19. The Croat tested positive only a day after returning to training having overcome a hamstring injury.
N’Golo Kante, Ben Chilwell and Jorginho will also sit out the match although Kai Havertz is set to be fit.
With this an early evening kick-off at 5.45pm GMT, check out below how to watch the match live on TV in the UK.
Where to watch Zenit vs Chelsea
TV channel: The Champions League game will be broadcast on BT Sport 3. Coverage begins at 5.15pm.
Live stream: BT Sport subscribers will be able to watch the game via the BT Sport website or app.
LIVE coverage: Get minute-by-minute updates with Standard Sport’s dedicated match blog. James Robson will be in Russia to deliver all the latest news.