UK

Matt Hancock blames new strain of coronavirus for surging cases in London and the South East

A mutated strain of coronavirus may be behind the rapid surge in infections in London and the South East of England, Matt Hancock suggested today.

UK experts have so far identified more than 1,000 cases of the variant, called VUI – 202012/01, the Health Secretary told the House of Commons.

There have been reports of the strain in at least 60 local authority areas and it is believed to be similar to ultra-infectious variants racing through Europe, he claimed. 

VUI – 202012/01 was picked up in Kent last week during routine testing by Public Health England (PHE) and ministers were alerted to its existence on Friday.

PHE scientists are studying the mutant strain at a Government laboratory in Porton Down to see if it behaves differently to the normal, predominant version of the virus. 

Experts will seek to find out if the variant is more infectious or deadly or if it will have any impact on Pfizer’s vaccine. It normally takes about two weeks to get the results. 

But Mr Hancock said there was ‘currently nothing to suggest’ the strain is more potent or causes more severe symptoms, adding that it is also ‘highly unlikely’ to be resistant to vaccines. 

So far little is known about VUI 202012/01 – which stands for Variant Under Investigation in December 2020 – or where it originated.  

All viruses naturally mutate as they spread through populations and the changes normally make minimal difference in the way they behave in humans.

Many pathogens evolve in order to become more infectious, which often makes them less deadly so they can survive for longer and be spread to more people.

Independent scientists said it was ‘too early to be worried or not by this new variant’ and that it would be ‘premature to make claims about the potential impacts of virus mutation’ before it has been rigorously studied.

A mutated strain of coronavirus may be the culprit behind a rapid surge in infections in London and the South East of England, Matt Hancock suggested today (file) 

Mr Hancock told MPs today: ‘Over the last few days, thanks to our world class genomic capability in the UK, we have identified a new variant of coronavirus which may be associated with the faster spread in the South East of England.

‘Initial analysis suggests this variant is growing faster than the existing variants. We have currently identified over 1,000 cases of this variant, predominantly in the South of England.

‘Although cases have been identified in nearly 60 different local authority areas and numbers are increasing rapidly. Similar variants have been identified in other countries over the last few months.

‘We’ve notified the World Health Organisation (WHO) about this new variant and Public Health England is working hard to continue its expert analysis at Porton Down.

WHAT IS KNOWN ABOUT THE NEW STRAIN? 

Experts have so far identified more than 1,000 confirmed cases in Britain;

There have been reports of the strain in at least 60 local authority areas in England; 

It has been named VUI 202012/01 – which stands for Variant Under Investigation in December 2020;

It was picked up in Kent last week during routine testing by Public Health England (PHE);

Ministers were alerted to its existence on Friday;

The strain is believed to be similar to ultra-infectious variants racing through Europe;

PHE scientists are studying the mutant strain at a Government laboratory in Porton Down;

There is ‘currently nothing to suggest’ the strain is more deadly or likely to cause serious symptoms than other versions of the virus;

‘Highly unlikely’ to be resistant to vaccines.

‘I must stress at this point there is currently nothing to suggest that this variant more likely to cause serious disease.

‘And the latest clinical advice is that it’s highly unlikely this mutation would fail to respond to a vaccine. But it shows we’ve got to be vigilant and follow the rules.

‘And everyone needs to take personal responsibility not to spread this virus.’

A spokesperson for the WHO told MailOnline: ‘We are aware of this variant coming from UK, which has been reported to us by the national authorities and we understand that they are looking at it.

‘It is normal for viruses to change. Most changes have little to no impact on the virus’ properties. 

‘However, depending on where the changes are located in the virus genetic material, and how these changes affect the virus’ shape or properties, some could potentially impact how it behaves and spreads.

‘If a virus changes so much that it is different from the one that vaccines are designed to combat, or tests to recognize, it may influence how well vaccines and diagnostic tests work. 

‘WHO, along with its network of experts, is monitoring changes to the virus so that if such a situation arises, measures can be taken to prevent the spread of that variant.

‘So far, the SARS-CoV-2 has changed very little having no impact on available diagnostics, therapeutics and vaccines that are in development.’

Reacting to the findings, Professor Jonathan Ball, a molecular virologist at the University of Nottingham, said: ‘The genetic information in many viruses can change very rapidly and sometimes these changes can benefit the virus – by allowing it to transmit more efficiently or to escape from vaccines or treatments – but many changes have no effect at all.

‘Even though a new genetic variant of the virus has emerged and is spreading in many parts of the UK and across the world, this can happen purely by chance. 

‘Therefore, it is important that we study any genetic changes as they occur, to work out if they are affecting how the virus behaves, and until we have done that important work it is premature to make any claims about the potential impacts of virus mutation.’

Professor Alan McNally, an expert in microbial evolutionary genomics at the University of Birmingham, added: ‘Over the past few weeks a few of the UK PCR testing labs have picked up on this new variant. 

‘Supported by The COVID-19 Genomics UK (COG-UK) consortium and rapid genomics it has been identified incredibly quickly.

‘Hopefully the narrative here is how amazing our surveillance has been at picking this up. Huge efforts are ongoing at characterising the variant and understanding its emergence. 

‘It is important to keep a calm and rational perspective on the strain as this is normal virus evolution and we expect new variants to come and go and emerge over time. 

‘It’s too early to be worried or not by this new variant, but I am in awe of the surveillance efforts in the UK that allowed this to be picked up so fast.’

The sole purpose of the virus is to replicate as many times as possible. Tiny changes in its DNA occur every time it spreads between people as it tries to enable greater growth, transmissibility or escape from the immune system.

But most of the changes have little to no effect and only rarely does a mutation occur that actually accomplishes one of these goals. This is a process than can take years, if not decades, with most viruses.

But some, such as the flu, mutate much quicker, which is why a different flu jab is created every year to protect millions of people against different strains. 

Experts are still uncertain how quickly SARS-CoV-2 mutates, but the consensus has been that this process is slower than flu, as is the case with other seasonal coronaviruses.

Another mutation in Sars-Cov-2, called D614G, was identified over summer and is still thriving in Europe, the US and parts of Asia. 

It is believed to make the virus more infectious but less deadly, which researchers believed was behind low hospital and death rates during the warmer months.

A different strain — called Cluster 5 — that emerged in mink over autumn was feared to make vaccines less potent after it was found to be resistant to antibodies, 

It was feared Cluster 5 would be able to slip past promising new Covid-19 vaccines, which work by stimulating an antibody response. 

Officials locked down swathes of northern Denmark where the strain originated and ordered the culling of 17million mink to stomp out the variant before it became widespread.  

 


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